澳门葡京赌博游戏的肿瘤学R&D战略
Driving innovation and exploring new frontiers to transform 癌症 outcomes

• 抗体药物偶联物(ADC): 的se targeted medicines deliver chemotherapy agents to 癌症 cells with monoclonal antibodies, joined via a chemical linker to cytotoxic drugs. This highly targeted and cell-specific mechanism has the potential to reduce side effects for those being treated with the drug. ¹
• Radioconjugates: This approach delivers the radiation therapy to tumour cells, enabling 癌症 cells to be destroyed in a more targeted manner than traditional external beam radiation, offering more tailored treatments for patients.
• DNA损伤反应(DDR): DNA损伤是一个关键因素 tumour progression and most 癌症s have a greater dependency on this process. DDR inhibitors block specific components of the DNA damage response pathways in 癌症 cells, causing 癌症 cell death while leaving healthy cells intact. ² 
• 肿瘤驱动因素和耐药性: We are developing therapies that directly target specific mutations and block resistance mechanisms that cause 癌症 cells to proliferate, with the goal of extending survival by targeting biological pathways and combating 癌症 as it evolves.
• 实验胚胎学: 失调的 表观遗传过程 can result in disease initiation and is a hallmark of 癌症. By studying how these epigenetic malfunctions lead to 癌症, we can develop therapies to target those changes.^3,4
• Immuno-oncology (IO): 澳门葡京赌博游戏正在开发下一代 IO 疗法 to empower the immune system to more effectively recognise and kill 癌症 cells and to overcome the immunosuppressive mechanisms that 癌症s frequently develop as they evolve. We are focusing on novel combinations of IO therapies and designing bispecific antibodies that simultaneously target different immune checkpoints on the same cell.
• 免疫衔接器: 人们越来越感兴趣的领域是 t细胞衔接器 which redirect the immune system's T-cells to recognise and kill 癌症 cells, thereby amplifying a patient’s own anti-癌症 immune response.⁵
• 细胞疗法: We are building a pipeline of next-generation cell therapies that are designed to overcome current barriers to the widespread adoption of cell therapies for both solid and haematological tumours, such as challenges in scalability and accessibility. 澳门葡京赌博游戏收购了Neogene therapeutics, we are expanding into T-cell receptor therapies (TCR-T), unlocking new space in 癌症 biology by targeting intracellular targets.⁶

Real potential is in combinations of 癌症 therapies for deeper, 更持久的反应

We believe that real potential is in the combination of treatments, 从多个角度攻击癌细胞. 的 breadth and depth of our portfolio allows us to trial many of these combinations to achieve a more durable, deeper response as we strive towards our ambition of transforming 癌症 outcomes and increasing the chance of cures. 

We are working towards a future where conventional chemotherapy and radiotherapy are replaced with targeted combinations of ADCs, 分子靶向治疗, 和免疫疗法. 

例如, combining ADCs that directly kill 癌症 cells with immunotherapies that drive the patient’s own immune response and support the tissue microenvironment to eradicate the tumour, may help drive stronger and more durable patient responses. We are also exploring the potential for maximising DNA damage induced 癌症 cell death by combining ADCs with DDR inhibitors.
 

更早、更聪明地治疗癌症
 

澳门葡京赌博游戏正在探索使用 循环肿瘤DNA (ctDNA), 检测癌症, choose the right treatments for patients and to determine just how effective treatment is.

We have a collaboration with the company GRAIL to develop blood-based companion diagnostics for early-stage 癌症. 通过这次合作, we will leverage GRAIL’s multi-癌症 early detection test to recruit patients onto 临床 trials for the investigation of our 癌症 treatments in early 癌症. 的 test not only includes the potential 检测癌症s with limited screening options at present but also importantly tells you which tissues they come from.⁷
 

以变革性技术领先
 

数据与人工智能

只要掌握了正确的数据, we can transform 癌症 drug discovery and development to get new treatments to patients faster. 数据与人工智能 嵌入澳门葡京赌博游戏所有的R&D活动, from identification of new targets for novel 癌症 medicines, 预测要制造哪些分子, 更好地预测临床成功, 通知, 加快临床试验招募. 数据与人工智能 is enabling us to harness new technology, automate processes and push the boundaries of science to accelerate innovation and the delivery of life-changing medicines.

计算病理学

计算病理学 is the integration of machine learning and digital imaging with traditional pathology techniques as next generation diagnostics. Advances in data science and computing now allow us to integrate data from immunohistochemically stained 癌症 tissue images with genomic, 放射学, 临床, 还有其他数据, applying deep learning algorithms to gain novel insights. 

Quantitative Continuous Scoring (QCS) is our novel, fully automated 计算病理学 solution that not only looks for the presence or absence of a biomarker but also quantifies the intensity of staining and its location in sub-cellular compartments. 现在, we’re pioneering the use of QCS within our 临床 trial portfolio, with regulatory approval as a first-in-class AI-driven diagnostic as a future goal.

数字医疗

的 数字的能力 澳门葡京赌博游戏在R上嵌入&D are essential to creating a seamless connectivity between people and data. Our ambition is to reimagine healthcare – transforming patients’ healthcare journeys to improve earlier diagnosis, more precision treatments and proactive digital monitoring for better outcomes, 数字化驱动, 纵向数据与人工智能, 通过最近推出的Evinova, our global health-tech business we’re even closer to this ambition.

澳门葡京赌博游戏还在继续研究, 创建和提供数字医疗解决方案, 通过Evinova, 都是有科学依据的, evidence-led, 人类的经验驱动. Deliberately designed so that everyone can reach better health outcomes together.

肿瘤学的未来&D

It is the combination of all these elements that we believe sets us up for future success. 通过结合这些创新, we will hopefully transform outcomes and survival for 癌症 patients.