写的:
肿瘤转化医学副总裁&D、澳门葡京网赌游戏
副总裁，癌症生物标志物开发，肿瘤R&D、澳门葡京网赌游戏
什么是转化科学?
Translational science is the process of translating research discovery into actionable insights in the clinic, 同时利用临床数据进一步发现造福患者. 在澳门葡京网赌游戏, 转化科学在开发精准药物方面发挥着关键作用, 作为早期科学突破之间的纽带, their application in clinical decision making and the development of 下一代诊断. 这一迅速发展的领域正在扩大澳门葡京赌博游戏对肿瘤生物学的认识, 最先进的生物标志物, and informing the design of innovative clinical trials which have the potential to transform outcomes for patients.
解决患者对癌症药物反应的差异
The varied responses that patients have to medicines make it challenging to develop new treatments that work for everyone. 尽管有相同的癌症诊断, 每个病人都有独特的分子特征，影响他们对治疗的反应. 这些差异, 由基因组成的变化引起的, 肿瘤突变状态, 目标表达式, 表观基因组学等等, 是否复杂并已将研发重点转向 精密医学.
增进澳门葡京赌博游戏的了解, translational science plays a key role in decoding which patients are likely to respond to treatment, 是什么因素促成了他们的反应, 在这个过程中澳门葡京赌博游戏可以了解到药物的作用机制. One way to approach this is to observe patient response to treatment and seek novel mechanistic insights. 例如, elimination of malignant cells during treatment represents an important moment for recovery but also provides valuable insights into how their unique molecular profile responded to treatment.
然而，准确地评估和预测这是具有挑战性的. 传统的方法依赖于术后肿瘤组织的显微检查, 这个过程容易忽略残留的癌细胞. The future of improving assessment and shaping the 精密医学 landscape relies on translational science and innovative clinical trial design.
转化科学在研发中的作用是什么?
在澳门葡京网赌游戏, 澳门葡京赌博游戏正在通过缩小早期发现之间的差距来加速创新, 生物标志物鉴定与临床实践, 通知…的发展 下一代诊断 哪些有可能改善患者的预后.
通过与澳门葡京赌博游戏的癌症生物标志物开发团队的密切合作, 澳门葡京赌博游戏正在寻找治疗反应的新预测因素, 目的是更早地选择和治疗病人, 尽量减少治疗带来的不良影响, 并帮助设计基于严谨科学的创新临床试验.
创新的翻译技术
随着澳门葡京赌博游戏深入研究肿瘤生物学的复杂性, the volume of data generated with cutting-edge technologies is empowering us to interrogate tumours with unprecedented precision. This more granular understanding is fuelling the development of next-generation diagnostics and transforming clinical decision-making.
用人工智能革新目标量化
在这一转变的前沿是 计算病理学, which harnesses the power of artificial intelligence (AI) to analyse tumours at a level of precision, 准确性和可重复性是以前无法想象的. 澳门葡京赌博游戏团队开发的其中一种方法是定量连续评分(QCS)。.
QCS检测生物标志物的存在与否, 量化其在亚细胞区室中的位置, 比如膜, 细胞质和细胞核, and analyses the biomarker in the context of the broader spatial organisation of the tissue. It is becoming invaluable for understanding the mechanism of action of targeted therapies, such as 抗体药物配合，并用于识别最有可能从治疗中受益的患者. 澳门葡京赌博游戏正在将QCS嵌入到澳门葡京赌博游戏的投资组合中, with the goal of gaining regulatory approval as a first-in-class set of 计算病理学 AI-driven predictive biomarkers.
更高清晰度的多模态生物标志物
澳门葡京赌博游戏还通过深度研究率先开发了多模态生物标志物 multiomic分析，整合分子、遗传和成像数据. These comprehensive biomarkers aim to simplify and streamline clinical decision-making by leveraging multiple elements of disease at a molecular level.
生物标志物是分子标记, which guide scientists and clinicians through the intricate complexities of the landscape of cancer, revealing hidden pathways and providing crucial clues to its dependencies and vulnerabilities. These markers are essential in transforming our understanding of tumour biology into benefit for our patients. 澳门葡京赌博游戏要靠他们来确定正确的目标, 在病人治疗的最佳阶段为他们提供正确的治疗
与传统的生物标志物不同, 哪一个通常只评估一个变量, 多模式生物标志物提供了一个 疾病全景图，使诊断和治疗能够采用综合方法. This allows us to better define treatment strategies tailored to each patient's unique tumour profile. 这些方法是澳门葡京赌博游戏试验的核心, 这是澳门葡京赌博游戏遵循科学指导临床决策的关键方式.
澳门葡京赌博游戏还可以通过血液追踪肿瘤动态 ctDNA剖析 帮助澳门葡京赌博游戏了解患者对治疗反应的差异. We are routinely including ctDNA analysis as a secondary endpoint in many of our clinical trials and to monitor minimal residual disease after surgery. 非侵入性ctDNA分析正在改变检测癌症的方式, 治疗和监测, providing predictive insights on patient selection and drug resistance to inform 精密医学 strategies.
通过创新试验回答翻译问题
从转型技术中获得的见解, 比如ctDNA分析, 计算病理学和深度多组分析, 革命不仅是诊断和预后，而且是临床试验设计. 利用新颖的见解, 澳门葡京赌博游戏正在设计澳门葡京赌博游戏的试验，以战略性地解决翻译问题, 目的是使病人的利益最大化.
例如, 之前通过收集肿瘤样本, 治疗期间和治疗后, 澳门葡京赌博游戏可以更好地理解肿瘤动力学. This includes "window-of-opportunity” studies which focus on the time between diagnosis and the initiation of treatment when tumours remain untouched by therapy and present an opportunity to study the molecular characteristics that define cancer cells.
以这种方式, 创新的临床试验设计使澳门葡京赌博游戏能够识别生物标志物, 基因突变, and other factors that inform rational treatment decisions and contribute to the ongoing development of more personalised and effective therapies.
准备迎接更深远的影响
Our 学术 backgrounds ignited a shared passion for decoding the secrets of cancer biology. 在澳门葡京网赌游戏, we are dedicated to nurturing this passion through close collaboration with our world-class colleagues and the wider biopharmaceutical, 学术, 监管机构和临床社区.
Translational science is at the heart of the revolution in oncology research and development, 定位为实验室和临床发现的催化剂, and underpinning the development of 下一代诊断 and predictive biomarkers. Our progress will be defined by our ability to reshape our understanding of tumour biology, 可靠预测治疗反应和耐药性, 并从多个角度寻找新的治疗癌症的方法.
加入澳门葡京赌博游戏，澳门葡京赌博游戏将继续寻找改变患者的方法
澳门葡京赌博游戏欢迎, 才华横溢的科学家们加入澳门葡京赌博游戏，这将是最令人兴奋的事情之一, 21世纪医学的刺激和有益之旅.
全球肿瘤学领域的领导者, we are growing a differentiated pipeline to address a range of tumour types associated with significant unmet need. There are limitless opportunities to make your mark, take smart risks and pioneer new ideas. 不同的经验和方法, our team shares a passion to follow the science and bring life-changing medicines to people across the globe.
We recruit scientists with relevant expertise to join us in our state-of-the-art facilities in Barcelona, 西班牙和 盖瑟斯堡,美国.
